SAMe

SAMe levels tend to decline as people age. In addition, SAMe is used in the production of the mood-elevating neurotransmitter serotonin as a methyl donor. Low levels of SAMe have been associated with certain mood challenges.

Clinical Applications

Detox Support and Antioxidant Protection

SAMe is an essential molecule in the synthesis of glutathione, a key component of antioxidant and detoxification. Studies show SAMe supports liver health and positively affects the cell-life regulation of hepatocytes.

Mood Health

SAMe appears to support mood health, possibly due to its active role in methylation and involvement in the formation of monoamine neurotransmitters. 

Folate

Folate is a water-soluble member of the B-complex vitamins that is critical for maintaining optimal methylation pathways. Malabsorption and genetic defects in the enzyme 5-methyltetrahydrofolate reductase (5-MTHFR) can result in an impaired ability to activate folic acid. Folic acid supports the trans-methylation pathway, which metabolizes homocysteine into cysteine. Increases in oxidative stress may shift homocysteine metabolism towards trans-sulfuration to increase hepatic production of reduced glutathione.